Chemical approaches to the discovery and development of cancer therapies

被引：210

作者：

Neidle, S

Thurston, DE

机构：

[1] Univ London, Sch Pharm, Canc Res UK Biomol Struct Grp, London WC1N 1AX, England

[2] Univ London, Sch Pharm, Gene Targeted Drug Design Res Grp, London WC1N 1AX, England

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrc1587

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chemical sciences are essential for the process of anticancer-drug discovery, and a range of chemical research techniques is needed to develop clinically effective drugs. Improved understanding of the cellular, molecular and genetic basis of cancer has increased the number of drug targets available. What chemical approaches are used to develop agents that target specific features of cancer cells and make these therapeutics more effective? We outline the roles that chemical synthesis and understanding of drug uptake have had in drug discovery over the past 100 years, as well as the chemical insights derived from knowledge of the three-dimensional structure of targets.

引用

页码：285 / 296

页数：12

共 82 条

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