Synthesis of the JKLM-ring fragment of ciguatoxin

被引：67

作者：

Baba, T ^{[1
]}

Huang, G ^{[1
]}

Isobe, M ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Organ Chem Lab, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON | 2003年 / 59卷 / 35期

关键词：

ciguatoxin; lactone; spiroketalization;

D O I：

10.1016/S0040-4020(03)00873-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of the LM-ring fragment has been achieved starting from a sugar derivative. A stereoselective synthesis of the JKLM-ring fragment has been achieved through a coupling between two segments via heteroconjugate addition, seven-membered ether ring formation mediated by an acetylene cobalt complex, and spiroketalization reaction. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6851 / 6872

页数：22

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