Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity

被引：26

作者：

Breitbach, Anthony S. ^{[1
]}

Broderick, Adam H. ^{[2
]}

Jewell, Christopher M. ^{[2
]}

Gunasekaran, Suvai ^{[2
]}

Lin, Qi ^{[1
]}

Lynn, David M. ^{[1
,2
]}

Blackwell, Helen E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 01期

关键词：

ACYLATED HOMOSERINE LACTONES; TO-CELL COMMUNICATION; DRUG;

D O I：

10.1039/c0cc02316g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.

引用

页码：370 / 372

页数：3

共 26 条

[1] Biodegradation and biocompatibility of PLA and PLGA microspheres [J].

Anderson, JM ;

Shive, MS .

ADVANCED DRUG DELIVERY REVIEWS, 1997, 28 (01) :5-24

[2] Bacterial small-molecule signaling pathways [J].

Camilli, A ;

Bassler, BL .

SCIENCE, 2006, 311 (5764) :1113-1116

[3] The biology and future prospects of antivirulence therapies [J].

Cegelski, Lynette ;

Marshall, Garland R. ;

Eldridge, Gary R. ;

Hultgren, Scott J. .

NATURE REVIEWS MICROBIOLOGY, 2008, 6 (01) :17-27

[4]

Chen GP, 2002, MACROMOL BIOSCI, V2, P67, DOI 10.1002/1616-5195(20020201)2:2<67::AID-MABI67>3.0.CO

[5]

2-F

[6] Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres [J].

Fu, K ;

Pack, DW ;

Klibanov, AM ;

Langer, R .

PHARMACEUTICAL RESEARCH, 2000, 17 (01) :100-106

[7] Regulation of gene expression by cell-to-cell communication: Acyl-homoserine lactone quorum sensing [J].

Fuqua, C ;

Parsek, MR ;

Greenberg, EP .

ANNUAL REVIEW OF GENETICS, 2001, 35 :439-468

[8] Listening in on bacteria: Acyl-homoserine lactone signalling [J].

Fuqua, C ;

Greenberg, EP .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (09) :685-695

[9] Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria [J].

Geske, Grant D. ;

O'Neill, Jennifer C. ;

Blackwell, Helen E. .

CHEMICAL SOCIETY REVIEWS, 2008, 37 (07) :1432-1447

[10] Comparative analyses of N-acylated homoserine Lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing [J].

Geske, Grant D. ;

ONeill, Jennifer C. ;

Miller, David M. ;

Wezeman, Rachel J. ;

Mattmann, Margrith E. ;

Lin, Qi ;

Blackwell, Helen E. .

CHEMBIOCHEM, 2008, 9 (03) :389-400

← 1 2 3 →