Parathyroid glands in calcium regulation and human disease

被引：25

作者：

Åkerström, G ^{[1
]}

Hellman, P ^{[1
]}

Hessman, O ^{[1
]}

Segersten, U ^{[1
]}

Westin, G ^{[1
]}

机构：

[1] Univ Hosp, Dept Surg Sci, SE-75185 Uppsala, Sweden

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

bone; calcium; disease; hypercalcemia; hyperparathyroidism (HPT); parathyroid glands; parathyroid hormone (PTH); vitamin D;

D O I：

10.1196/annals.1327.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In humans and other land-living vertebrates, the parathyroids are known to have an overall regulatory role with action as a thermostat in the systemic calcium homeostasis to ensure tight regulation of serum calcium concentrations and appropriate skeletal mineralization. Parathyroid hormone (PTH) is an 84-amino-acid peptide, synthesized and released by parathyroid chief cells in response to hypocalcentia. PTH mobilizes calcium by increasing calcium resorption from bone and by raising calcium reabsorption in the proximal kidney tubule. Treatment with active vitamin D can increase vitamin D receptor expression, inhibit growth of parathyroid tumors, and reduce PTH levels in patients with hyperparathyroidism (HPT). Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT.

引用

页码：53 / 58

页数：6

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