Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs

被引：23

作者：

Kim, Sang-Hoon ^{[2
]}

Kim, Sang-Heon ^{[3
]}

Lee, Jae-Hyung ^{[2
]}

Lee, Byoung-Hoon ^{[2
]}

Kim, Youn-Seup ^{[1
]}

Park, Jae-Seuk ^{[1
]}

Jee, Young-Koo ^{[1
]}

机构：

[1] Dankook Univ, Coll Med, Dept Internal Med, Cheonan, South Korea

[2] Eulji Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[3] Hanyang Univ, Coll Med, Dept Internal Med, Seoul 133791, South Korea

来源：

TUBERCULOSIS | 2012年 / 92卷 / 01期

关键词：

Drug transporter; Antituberculosis drug; Hepatitis; INDUCED HEPATOTOXICITY; METABOLIZING-ENZYMES; SUSCEPTIBILITY; RISK; MUTATIONS; HAPLOTYPE; GENOTYPE;

D O I：

10.1016/j.tube.2011.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Unusual drug accumulation is a common mechanism underlying serious drug-induced liver injury. Polymorphisms in three drug transporter genes (ABCB1, SLCO1B1 and ABCC2) may be risk markers for hepatitis induced by the unusual accumulation of anti-tuberculosis drugs (ATDs). We therefore investigated whether polymorphisms and haplotypes of these genes are associated with ATD-induced hepatitis by comparing the frequencies and distributions of single nucleotide polymorphisms and haplotypes of these three drug transporter genes among 67 patients with ATD-induced hepatitis and 159 patients tolerant to ATDs using a multivariate logistic regression analysis. We found that the frequencies of polymorphisms and haplotypes of ABCB1, SLCO1B1 and ABCC2 were similar in patients with ATD-induced hepatitis and ATD-tolerant controls. The present results suggest that these drug transporters do not play important roles in the pathogenesis of ATD-induced hepatitis in Korean patients. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：100 / 104

页数：5

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