Structural features of single amino acid repeats in proteins

被引：5

作者：

Subirana, JA

Palau, J

机构：

[1] Univ Politecn Catalunya, ETSEIB, Dept Engn Quim, E-08028 Barcelona, Spain

[2] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unit Biotecnol Computac, E-43005 Tarragona, Spain

来源：

FEBS LETTERS | 1999年 / 448卷 / 01期

关键词：

amino acid sequence; protein structure; nucleotide sequence; glutamine; neurological disease; protein aggregation;

D O I：

10.1016/S0014-5793(99)00310-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single amino acid repeats are found in different kinds of proteins. Some of these repeats are pathogenic. It is striking that some amino acids are able to form such repeats, but other amino acids are not. We suggest an explanation for this fact based on the different tendency of each amino acid to form aggregates. Aggregation may be due to the formation of incipient lamellar crystals as they have been described in poly-alpha-amino acids and in most synthetic polymers. (C) 1999 Federation of European Biochemical Societies.

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页码：1 / 3

页数：3

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