The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

被引：814

作者：

Christofori, G

Semb, H

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

[2] Univ Gothenburg, Inst Med Biochem, S-40530 Gothenburg, Sweden

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(98)01343-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion. might also convey signals that actively induce tumour-cell invasion and metastasis.

引用

收藏

页码：73 / 76

页数：4

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