Molecular regulation of microlymphatic formation and function: Role of nitric oxide

被引：15

作者：

Hagendoorn, J

Padera, TP

Fukumura, D

Jain, RK ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, EL Steele Lab Tumor Biol, Dept Radiat Oncol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2005年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.tcm.2005.06.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.

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收藏

页码：169 / 173

页数：5

相关论文

共 47 条

[1]

ACHEN MG, 1995, CANCER CELL, V7, P121

[2] Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].

Aicher, A ;

Heeschen, C ;

Mildner-Rihm, C ;

Urbich, C ;

Ihling, C ;

Technau-Ihling, K ;

Zeiher, AM ;

Dimmeler, S .

NATURE MEDICINE, 2003, 9 (11) :1370-1376

[3]

Altman Peter A, 2003, Lymphat Res Biol, V1, P47, DOI 10.1089/15396850360495691

[4]

An Andrew, 2004, Lymphat Res Biol, V2, P173, DOI 10.1089/lrb.2004.2.173

[5] INTERSTITIAL-LYMPHATIC MECHANISMS IN THE CONTROL OF EXTRACELLULAR FLUID VOLUME [J].

AUKLAND, K ;

REED, RK .

PHYSIOLOGICAL REVIEWS, 1993, 73 (01) :1-78

[6] Vascular endothelial growth factor d is dispensable for development of the lymphatic system [J].

Baldwin, ME ;

Halford, MA ;

Roufail, S ;

Williams, RA ;

Hibbs, ML ;

Grail, D ;

Kubo, H ;

Stacker, SA ;

Achen, MG .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (06) :2441-2449

[7] CHARACTERIZATION OF INTACT MESENTERIC LYMPHATIC PUMP AND ITS RESPONSIVENESS TO ACUTE EDEMAGENIC STRESS [J].

BENOIT, JN ;

ZAWIEJA, DC ;

GOODMAN, AH ;

GRANGER, HJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (06) :H2059-H2069

[8] Transport in lymphatic capillaries .2. Microscopic velocity measurement with fluorescence photobleaching [J].

Berk, DA ;

Swartz, MA ;

Leu, AJ ;

Jain, RK .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 270 (01) :H330-H337

[9] Interstitial flow as a guide for lymphangiogenesis [J].

Boardman, KC ;

Swartz, MA .

CIRCULATION RESEARCH, 2003, 92 (07) :801-808

[10] PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis [J].

Cao, RH ;

Björndahl, MA ;

Religa, P ;

Clasper, S ;

Garvin, S ;

Galter, D ;

Meister, B ;

Ikomi, F ;

Tritsaris, K ;

Dissing, S ;

Ohhashi, T ;

Jackson, DG ;

Cao, YH .

CANCER CELL, 2004, 6 (04) :333-345

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