Exposing gliadin as a tasty food for lymphocytes

被引：56

作者：

Schuppan, D ^{[1
]}

Dieterich, W

Riecken, EO

机构：

[1] Univ Erlangen Nurnberg, Dept Med 1, D-91054 Erlangen, Germany

[2] Free Univ Berlin, D-12200 Berlin, Germany

来源：

NATURE MEDICINE | 1998年 / 4卷 / 06期

关键词：

D O I：

10.1038/nm0698-666

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deamidation of wheat gliadin by tissue transglutaminase promotes its binding to HLA-DQ2 and its recognition by gut T cells, suggesting a novel mechanism in celiac disease (pages 713–717).

引用

页码：666 / 667

页数：2

共 11 条

[1] Identification of tissue transglutaminase as the autoantigen of celiac disease
Dieterich, W
Ehnis, T
Bauer, M
Donner, P
Volta, U
Riecken, EO
Schuppan, D
[J]. NATURE MEDICINE, 1997, 3 (07) : 797 - 801
[2] CYTOKINE MODULATION OF INTESTINAL EPITHELIAL-CELL RESTITUTION - CENTRAL ROLE OF TRANSFORMING GROWTH-FACTOR-BETA
DIGNASS, AU
PODOLSKY, DK
[J]. GASTROENTEROLOGY, 1993, 105 (05) : 1323 - 1332
[3] Celiac disease autoantibodies and tissue transglutaminase antibodies interfere similarly fibroblast-induced epithelial cell (T84) differentiation.
Halttunen, T
Mäki, M
[J]. GASTROENTEROLOGY, 1998, 114 (04) : A377 - A377
[4] Binding of peptides from the N-terminal region of alpha-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays
Johansen, BH
Gjertsen, HA
Vartdal, F
Buus, S
Thorsby, E
Lundin, KEA
Sollid, LM
[J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 79 (03): : 288 - 293
[5] GLUTEN, MAJOR HISTOCOMPATIBILITY COMPLEX, AND THE SMALL-INTESTINE - A MOLECULAR AND IMMUNOBIOLOGICAL APPROACH TO THE SPECTRUM OF GLUTEN SENSITIVITY (CELIAC SPRUE)
MARSH, MN
[J]. GASTROENTEROLOGY, 1992, 102 (01) : 330 - 354
[6] MARSH MN, 1997, NAT MED, V3, P125
[7] Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
Molberg, O
Mcadam, SN
Körner, R
Quarsten, H
Kristiansen, C
Madsen, L
Fugger, L
Scott, H
Norén, O
Roepstorff, P
Lundin, KEA
Sjöström, H
Sollid, LM
[J]. NATURE MEDICINE, 1998, 4 (06) : 713 - 717
[8] Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
Nunes, I
Gleizes, PE
Metz, CN
Rifkin, DB
[J]. JOURNAL OF CELL BIOLOGY, 1997, 136 (05) : 1151 - 1163
[9] Pender SLF, 1997, J IMMUNOL, V158, P1582
[10] HLA SUSCEPTIBILITY GENES IN CELIAC-DISEASE - GENETIC-MAPPING AND ROLE IN PATHOGENESIS
SOLLID, LM
THORSBY, E
[J]. GASTROENTEROLOGY, 1993, 105 (03) : 910 - 922

← 1 2 →