共 67 条
Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro
被引:68
作者:

Arthur, JL
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机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Scarpini, CG
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机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Connor, V
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机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Lachmann, RH
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机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Tolkovsky, AM
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机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Efstathiou, S
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机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England
机构:
[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England
[2] Univ Cambridge, Dept Med, Cambridge CB2 1QP, England
[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1QP, England
关键词:
D O I:
10.1128/JVI.75.8.3885-3895.2001
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
A neonatal rat dorsal root ganglion-derived neuronal culture system has been utilized to study herpes simplex virus (HSV) latency establishment, maintenance, and reactivation. We present our initial characterization of viral gene expression in neurons following infection,vith replication-defective HSV recombinants carrying beta -galactosidase and/or green fluorescent protein reporter genes under the control of lytic cycle- or latency-associated promoters. In this system lytic virus reporter promoter activity was detected in up to 58% of neurons 24 h after infection. Lytic cycle reporter promoters were shut dean over time, and long-term survival of neurons harboring latent virus genomes was demonstrated. Latency-associated promoter-driven reporter gene expression was detected in neurons from early times postinfection and was stably maintained in up to 83% of neurons for at least 3 weeks. In latently infected cultures, silent lytic cycle promoters could be activated in up to 53% of neurons by nerve growth factor withdrawal or through inhibition of histone deacetylases by trichostatin A. We conclude that the use of recombinant viruses containing reporter genes, under the regulation of lytic and latency promoter control in neuronal cultures in which latency can be established and reactivation can be induced, is a potentially powerful system in which to study the molecular events that occur during HSV infection of neurons.
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页码:3885 / 3895
页数:11
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共 67 条
[1]
Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection
[J].
Alvira, MR
;
Goins, WF
;
Cohen, JB
;
Glorioso, JC
.
JOURNAL OF VIROLOGY,
1999, 73 (05)
:3866-3876

Alvira, MR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Goins, WF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Cohen, JB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Glorioso, JC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA
[2]
INTRANUCLEAR FOCI CONTAINING LOW ABUNDANCE HERPES-SIMPLEX VIRUS LATENCY-ASSOCIATED TRANSCRIPTS VISUALIZED BY NONISOTOPIC IN-SITU HYBRIDIZATION
[J].
ARTHUR, J
;
EFSTATHIOU, S
;
SIMMONS, A
.
JOURNAL OF GENERAL VIROLOGY,
1993, 74
:1363-1370

ARTHUR, J
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI, DIV MED VIROL, ADELAIDE, SA 5000, AUSTRALIA INST MED & VET SCI, DIV MED VIROL, ADELAIDE, SA 5000, AUSTRALIA

EFSTATHIOU, S
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI, DIV MED VIROL, ADELAIDE, SA 5000, AUSTRALIA INST MED & VET SCI, DIV MED VIROL, ADELAIDE, SA 5000, AUSTRALIA

SIMMONS, A
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI, DIV MED VIROL, ADELAIDE, SA 5000, AUSTRALIA INST MED & VET SCI, DIV MED VIROL, ADELAIDE, SA 5000, AUSTRALIA
[3]
Disruption of the 5′ and 3′ splice sites flanking the major latency-associated transcripts of herpes simplex virus type 1:: evidence for alternate splicing in lytic and latent infections
[J].
Arthur, JL
;
Everett, R
;
Brierley, I
;
Efstathiou, S
.
JOURNAL OF GENERAL VIROLOGY,
1998, 79
:107-116

Arthur, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Everett, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

论文数: 引用数:
h-index:
机构:

Efstathiou, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England
[4]
A study of primary neuronal infection by mutants of herpes simplex virus type 1 lacking dispensable and non-dispensable glycoproteins
[J].
Babic, N
;
Rodger, G
;
Arthur, J
;
Minson, AC
.
JOURNAL OF GENERAL VIROLOGY,
1999, 80
:2403-2409

Babic, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Rodger, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Arthur, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

Minson, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England
[5]
LONG-TERM HERPES-SIMPLEX VIRUS TYPE-1 INFECTION OF NERVE GROWTH FACTOR-TREATED PC12 CELLS
[J].
BLOCK, T
;
BARNEY, S
;
MASONIS, J
;
MAGGIONCALDA, J
;
VALYINAGY, T
;
FRASER, NW
.
JOURNAL OF GENERAL VIROLOGY,
1994, 75
:2481-2487

BLOCK, T
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104 WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

BARNEY, S
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104 WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

MASONIS, J
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104 WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

MAGGIONCALDA, J
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104 WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

VALYINAGY, T
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104 WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

FRASER, NW
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104 WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104
[6]
A HERPES-SIMPLEX VIRUS TYPE-1 LATENCY-ASSOCIATED TRANSCRIPT MUTANT REACTIVATES WITH NORMAL KINETICS FROM LATENT INFECTION
[J].
BLOCK, TM
;
SPIVACK, JG
;
STEINER, I
;
DESHMANE, S
;
MCINTOSH, MT
;
LIRETTE, RP
;
FRASER, NW
.
JOURNAL OF VIROLOGY,
1990, 64 (07)
:3417-3426

BLOCK, TM
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104

SPIVACK, JG
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104

STEINER, I
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104

DESHMANE, S
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104

MCINTOSH, MT
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104

LIRETTE, RP
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104

FRASER, NW
论文数: 0 引用数: 0
h-index: 0
机构:
WISTAR INST,PHILADELPHIA,PA 19104 WISTAR INST,PHILADELPHIA,PA 19104
[7]
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation
[J].
Bloom, DC
;
Hill, JM
;
DeviRao, G
;
Wagner, EK
;
Feldman, LT
;
Stevens, JG
.
JOURNAL OF VIROLOGY,
1996, 70 (04)
:2449-2459

Bloom, DC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095

Hill, JM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095

DeviRao, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095

Wagner, EK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095

Feldman, LT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095

Stevens, JG
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095
[8]
A Genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease
[J].
Boursnell, MEG
;
Entwisle, C
;
Blakeley, D
;
Roberts, C
;
Duncan, IA
;
Chisholm, SE
;
Martin, GM
;
Jennings, R
;
Challanain, DN
;
Sobek, I
;
Inglis, SC
;
McLean, CS
.
JOURNAL OF INFECTIOUS DISEASES,
1997, 175 (01)
:16-25

Boursnell, MEG
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Entwisle, C
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Blakeley, D
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Roberts, C
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Duncan, IA
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Chisholm, SE
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Martin, GM
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Jennings, R
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Challanain, DN
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Sobek, I
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

Inglis, SC
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

McLean, CS
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND UNIV SHEFFIELD, SCH MED, DEPT EXPT & CLIN MICROBIOL, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND
[9]
Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture
[J].
Chen, XP
;
Li, J
;
Mata, M
;
Goss, J
;
Wolfe, D
;
Glorioso, JC
;
Fink, DJ
.
JOURNAL OF VIROLOGY,
2000, 74 (21)
:10132-10141

Chen, XP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Li, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Mata, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Goss, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Wolfe, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Glorioso, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Fink, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA
[10]
REACTIVATION OF LATENT HERPES-SIMPLEX VIRUS-1 (HSV) FROM MOUSE FOOTPAD CELLS DEMONSTRATED BY INSITU HYBRIDIZATION
[J].
CLEMENTS, GB
;
JAMIESON, FE
.
ARCHIVES OF VIROLOGY,
1989, 104 (1-2)
:95-106

CLEMENTS, GB
论文数: 0 引用数: 0
h-index: 0

JAMIESON, FE
论文数: 0 引用数: 0
h-index: 0