High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA

被引：106

作者：

Mazzariol, A

Tokue, Y

Kanegawa, TM

Cornaglia, G

Nikaido, H

机构：

[1] Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94720 USA

[2] Univ Verona, Dept Pathol, Microbiol Sect, I-37100 Verona, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 12期

关键词：

D O I：

10.1128/AAC.44.12.3441-3443.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by greater than or equal to 170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, greater than or equal to 32 mug/ml) but not in any of the 15 isolates for which the MIC was less than or equal to1 mug/ml.

引用

页码：3441 / 3443

页数：3

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