Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2

被引：159

作者：

Eskelinen, EL

Cuervo, AM

Taylor, MRG

Nishino, I

Blum, JS

Dice, JF

Sandoval, IV

Lippincott-Schwartz, J

August, JT

Saftig, P

机构：

[1] Univ Kiel, Inst Biochem, D-2300 Kiel, Germany

[2] Johns Hopkins Med Singapore, Dept Oncol, Div Biomed Sci, Singapore, Singapore

[3] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[4] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA

[5] Univ Autonoma Madrid, Fac Ciencias, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[6] Tufts Univ, Sch Med, Boston, MA 02111 USA

[7] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA

[8] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neuromuscular Res, Tokyo, Japan

[9] Univ Colorado, Hlth Sci Ctr, Adult Med Genet Program, Aurora, CO 80010 USA

[10] Albert Einstein Coll Med, Bronx, NY 10461 USA

[11] Univ Helsinki, Dept Biol & Environm Sci, Div Biochem, Helsinki, Finland

来源：

TRAFFIC | 2005年 / 6卷 / 11期

关键词：

alternative splicing; isoforms; LAMP1; LAMP-1; LAMP2; LAMP-2; lysosome;

D O I：

10.1111/j.1600-0854.2005.00337.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.

引用

页码：1058 / 1061

页数：4

共 31 条

[1]

Normal lysosomal morphology and function in LAMP-1-deficient mice [J].