Cancer chemoprevention: lessons learned and future directions

被引：20

作者：

Brenner, DE ^{[1
]}

Gescher, AJ

机构：

[1] Univ Michigan, Dept Pharmacol, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

[2] VA Med Ctr, Ann Arbor, MI 48109 USA

[3] Univ Leicester, Dept Canc Studies, Canc Biomarkers & Prevent Grp, Leicester LE2 2LX, Leics, England

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 93卷 / 07期

关键词：

chemoprevention; neoplasia; biomarkers; nutrition; drug therapy;

D O I：

10.1038/sj.bjc.6602765

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The concept of delaying or preventing epithelial transformation remains a viable and attainable goal for the future. Drug-based strategies for chemoprevention of the future may predominantly rely upon targeted therapies with tolerable but defined toxicities for treatment of individuals diagnosed with intraepithelial neoplasias. Foods, diet manipulation strategies, or nutraceuticals may be more appropriate to delay or prevent carcinogenesis progression in healthy populations with genetic or epidemiologic evidence of risk for future transformation.

引用

页码：735 / 739

页数：5

共 36 条

[1] Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac [J].

Agarwal, B ;

Rao, CV ;

Bhendwal, S ;

Ramey, WR ;

Shirin, H ;

Reddy, BS ;

Holt, PR .

GASTROENTEROLOGY, 1999, 117 (04) :838-847

[2]

Aggarwal BB, 2004, ANTICANCER RES, V24, P2783

[3] What happened to the coxibs on the way to the cardiologist? [J].

Alberts, DS ;

Potter, JD ;

Martinez, ME ;

Hess, LM ;

Stopeck, A ;

Lance, P .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (03) :555-556

[4] Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas [J].

Alberts, DS ;

Martínez, ME ;

Roe, DJ ;

Guillén-Rodríguez, JM ;

Marshall, JR ;

van Leeuwen, JB ;

Reid, ME ;

Ritenbaugh, C ;

Vargas, PA ;

Bhattacharyya, AB ;

Earnest, DL ;

Sampliner, RE ;

Parish, D ;

Koonce, K ;

Fales, L .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (16) :1156-1162

[5] Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line [J].

Arico, S ;

Pattingre, S ;

Bauvy, C ;

Gane, P ;

Barbat, A ;

Codogno, P ;

Ogier-Denis, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) :27613-27621

[6] A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients [J].

Bairati, I ;

Meyer, F ;

Gélinas, M ;

Fortin, A ;

Nabid, A ;

Brochet, F ;

Mercier, JP ;

Têtu, B ;

Harel, F ;

Mâsse, B ;

Vigneault, E ;

Vass, S ;

del Vecchio, P ;

Roy, J .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (07) :481-488

[7] A randomized trial of aspirin to prevent colorectal adenomas [J].

Baron, JA ;

Cole, BF ;

Sandler, RS ;

Haile, RW ;

Ahnen, D ;

Bresalier, R ;

McKeown-Eyssen, G ;

Summers, RW ;

Rothstein, R ;

Burke, CA ;

Snover, DC ;

Church, TR ;

Allen, JI ;

Beach, M ;

Beck, GJ ;

Bond, JH ;

Byers, T ;

Greenberg, ER ;

Mandel, JS ;

Marcon, N ;

Mott, LA ;

Pearson, L ;

Saibil, F ;

van Stolk, RU .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (10) :891-899

[8] Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial [J].

Bresalier, RS ;

Sandler, RS ;

Quan, H ;

Bolognese, JA ;

Oxenius, B ;

Horgan, K ;

Lines, C ;

Riddell, R ;

Morton, D ;

Lanas, A ;

Konstam, MA ;

Baron, JA .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (11) :1092-1102

[9]

Corpet DE, 2003, CANCER EPIDEM BIOMAR, V12, P391

[10] Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling [J].

Deng, C ;

Lu, QJ ;

Zhang, ZY ;

Rao, T ;

Attwood, J ;

Yung, R ;

Richardson, B .

ARTHRITIS AND RHEUMATISM, 2003, 48 (03) :746-756

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