Synthesis of 3-alkenyl-Delta(2)-cephems by copper(I) chloride-promoted alkenylation of 3-trifluoromethylsulfonyloxy-Delta 3-cephem with alkenyltributyltins

被引：15

作者：

Tanaka, H ^{[1
]}

Sumida, S ^{[1
]}

Torii, S ^{[1
]}

机构：

[1] OKAYAMA UNIV,FAC ENGN,DEPT APPL CHEM,OKAYAMA 700,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 33期

关键词：

D O I：

10.1016/0040-4039(96)01289-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 3-alkenyl-Delta(2)-cephems 3 was performed in regioselective manner by copper(I) chloride-promoted alkenylation of 3-trifluoromethylsulfonyloxy-Delta(3)-cephem 1 with alkenyltributyltins. Subsequent Diels-Alder reaction of the 3-vinyl-Delta(2)-cephem 3a with acrolein opened a new access to C(2)-C(3) fused tricyclic cephalosporin 9. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5967 / 5970

页数：4

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