A novel cytotoxic flavonoid glycoside from Physalis angulata

被引：60

作者：

Ismail, N ^{[1
]}

Alam, M ^{[1
]}

机构：

[1] Univ Houston, Coll Pharm, Houston, TX 77204 USA

来源：

FITOTERAPIA | 2001年 / 72卷 / 06期

关键词：

Physalis angulata; flavonol glycosides; myricetin; 3-O-neohesperidoside; cytotoxicity;

D O I：

10.1016/S0367-326X(01)00281-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a Cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED50 values of 0.048, 0.50 and 0.55 mug ml(-1), respectively. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：676 / 679

页数：4

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