The allogeneic response and tumor immunity

被引：84

作者：

Fabre, JW ^{[1
]}

机构：

[1] Guys Kings & St Thomas Sch Med, Inst Liver Studies, Dept Clin Sci, London, England

来源：

NATURE MEDICINE | 2001年 / 7卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/89008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses. A patient's response to allogeneic MHC molecules might promote an effective T-cell response to self MHC-restricted tumor peptides and the possibilities for this are discussed here. These allogeneic responses might successfully be harnessed to promote the immune eradication of metastatic cancer.

引用

页码：649 / 652

页数：4

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