Interaction of PCBs with thyroid hormone levels and time of hatching in chicken embryos

被引：5

作者：

Beck, V

Roelens, SA

Maervoet, J

Schepens, P

Darras, VM

机构：

[1] Katholieke Univ Leuven, Inst Zool, Lab Comparat Endocrinol, Louvain, Belgium

[2] Univ Antwerp, Toxicol Ctr, B-2020 Antwerp, Belgium

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

polychlorinated biphenyls (PCBs); thyroid hormones (TH); chicken; development; hatching;

D O I：

10.1196/annals.1327.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of polychlorinated biphenyls (PCB 77, PCB 153, and the mixture Aroclor 1242) on circulating and intracellular thyroid hormone (TH) levels were studied during chicken embryonic development. We observed no influences of PCB 153 on TH availability. Aroclor 1242 caused a transient increase in the T-3 level in the cerebellum at day 16. Clear effects were only seen with PCB 77 around the period of hatching: a severely reduced TH peak, which normally coincides with the stage of internal pipping, and a considerable delay in the moment of hatching.

引用

页码：224 / 226

页数：3

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