Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat

被引：251

作者：

Meeran, K ^{[1
]}

O'Shea, D ^{[1
]}

Edwards, CMB ^{[1
]}

Turton, MD ^{[1
]}

Heath, MM ^{[1
]}

Gunn, I ^{[1
]}

Abusnana, S ^{[1
]}

Rossi, M ^{[1
]}

Small, CJ ^{[1
]}

Goldstone, AP ^{[1
]}

Taylor, GM ^{[1
]}

Sunter, D ^{[1
]}

Steere, J ^{[1
]}

Choi, SJ ^{[1
]}

Ghatei, MA ^{[1
]}

Bloom, SR ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll, Sch Med, Med Endocrine Unit, London W12 0HS, England

来源：

ENDOCRINOLOGY | 1999年 / 140卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1210/en.140.1.244

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Central nervous system glucagon-like peptide-1-(7-36) amide (GLP-1) administration has been reported to acutely reduce food intake in the rat. We here report that repeated intracerebroventricular (icv) injection of GLP-1 or the GLP-1 receptor antagonist, exendin-(9-39), affects food intake and body weight. Daily icy injection of 3 nmol GLP-1 to schedule-fed rats for 6 days caused a reduction in food intake and a decrease in body weight of 16 +/- 5 g (P < 0.02 compared with saline-injected controls). Daily icy administration of 30 nmol exendin-(9-39) to schedule-fed rats for 3 days caused an increase in food intake and increased body weight by 7 +/- 2 g (P < 0.02 compared with saline-injected controls). Twice daily icy injections of 30 nmol exendin-(9-39) with 2.4 nmol neuropeptide Y to ad libitum-fed rats for 8 days increased food intake and increased body weight by 28 +/- 4 g compared with 14 +/- 3 g in neuropeptide Y-infected controls (P < 0.02). There was no evidence of tachyphylaxis in response to icy GLP-1 or exendin-(9-39). GLP-1 may thus be involved in the regulation of body weight in the rat.

引用

页码：244 / 250

页数：7

共 58 条

[1] Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
Bullock, BP
Heller, RS
Habener, JF
[J]. ENDOCRINOLOGY, 1996, 137 (07) : 2968 - 2978
[2] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS
CAMPFIELD, LA
SMITH, FJ
GUISEZ, Y
DEVOS, R
BURN, P
[J]. SCIENCE, 1995, 269 (5223) : 546 - 549
[3] Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats
Davis, HR
Mullins, DE
Pines, JM
Hoos, LM
France, CF
Compton, DS
Graziano, MP
Sybertz, EF
Strader, CD
Van Heek, M
[J]. OBESITY RESEARCH, 1998, 6 (02): : 147 - 156
[4] GLUCAGON-LIKE PEPTIDE-1 BINDING TO RAT SKELETAL-MUSCLE
DELGADO, E
LUQUE, MA
ALCANTARA, A
TRAPOTE, MA
CLEMENTE, F
GALERA, C
VALVERDE, I
VILLANUEVAPENACARRILLO, ML
[J]. PEPTIDES, 1995, 16 (02) : 225 - 229
[5] DEUTSCH JA, 1977, NATURE, V266, P196, DOI 10.1038/266196a0
[6] Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats
Donahey, JCK
van Dijk, G
Woods, SC
Seeley, RJ
[J]. BRAIN RESEARCH, 1998, 779 (1-2) : 75 - 83
[7] EVIDENCE THAT NEUROPEPTIDE-Y IS A PHYSIOLOGICAL SIGNAL FOR NORMAL FOOD-INTAKE
DUBE, MG
XU, B
CROWLEY, WR
KALRA, PS
KALRA, SP
[J]. BRAIN RESEARCH, 1994, 646 (02) : 341 - 344
[8] ENG J, 1992, MT SINAI J MED, V59, P147
[9] Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
Erickson, JC
Hollopeter, G
Palmiter, RD
[J]. SCIENCE, 1996, 274 (5293) : 1704 - 1707
[10] Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
Erickson, JC
Clegg, KE
Palmiter, RD
[J]. NATURE, 1996, 381 (6581) : 415 - 418

← 1 2 3 4 5 6 →