Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells

被引：18

作者：

Cebrian-Torrejon, Gerardo ^{[1
]}

Kahn, Suzana Assad ^{[2
]}

Elena Ferreira, Maria ^{[3
]}

Thirant, Cecile ^{[2
]}

Rojas de Arias, Antonieta ^{[4
]}

Figadere, Bruno ^{[1
]}

Fournet, Alain ^{[5
]}

Chneiweiss, Herve ^{[2
]}

Poupon, Erwan ^{[1
]}

机构：

[1] Univ Paris 05, Fac Pharm, Lab Pharmacognosie Associe, CNRS,LabEx LERMIT,UMR BioCIS 8076, F-92296 Chatenay Malabry, France

[2] Univ Paris 05, INSERM, U894, Glial Plast Lab, Paris, France

[3] Univ Nacl Asuncion, Dept Trop Med, Inst Invest Ciencias Salud Asuncion, Asuncion, Paraguay

[4] Ctr Desarrollo Invest Cient CEDIC FMB Diaz Gill M, Asuncion, Paraguay

[5] Fac Pharm Chatenay Malabry, IRD, Lab Pharmacognosie, UMR 217, F-92296 Chatenay Malabry, France

来源：

MEDCHEMCOMM | 2012年 / 3卷 / 07期

关键词：

D O I：

10.1039/c2md20047c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Interesting selectivities for cancer stem cells versus neuronal stem cells are demonstrated in vitro with analogues of canthin-6-one, an indolic alkaloid isolated from Zanthoxylum chiloperone var. angustifolium (Rutaceae). The implication of the PI3/AKT signalling pathway is also disclosed.

引用

页码：771 / 774

页数：4

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