CO2/HCO3--responsive soluble adenylyl cyclase as a putative metabolic sensor

被引：96

作者：

Zippin, JH ^{[1
]}

Levin, LR ^{[1
]}

Buck, J ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Pharmacol, New York, NY 10021 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2001年 / 12卷 / 08期

关键词：

D O I：

10.1016/S1043-2760(01)00454-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO3-). As the concentration of HCO3- reflects cellular levels of carbon dioxide (CO2), energy-generating metabolic processes (which increase intracellular CO2) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.

引用

页码：366 / 370

页数：5

共 57 条

[1] RESISTANCE OF BRAIN PHOSPHOFRUCTO-1-KINASE TO PH-DEPENDENT INHIBITION
BAZAES, SE
KEMP, RG
[J]. METABOLIC BRAIN DISEASE, 1990, 5 (03) : 111 - 118
[2] STUDIES ON THE MECHANISM OF THE GLUCOSE-INDUCED CAMP SIGNAL IN GLYCOLYSIS AND GLUCOSE REPRESSION MUTANTS OF THE YEAST SACCHAROMYCES-CEREVISIAE
BEULLENS, M
MBONYI, K
GEERTS, L
GLADINES, D
DETREMERIE, K
JANS, AWH
THEVELEIN, JM
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (01): : 227 - 231
[3] DEVELOPMENT OF A MN2+-SENSITIVE, SOLUBLE ADENYLATE CYCLASE IN RAT TESTIS
BRAUN, T
DODS, RF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) : 1097 - 1101
[4] BRAUN T, 1991, METHOD ENZYMOL, V195, P130
[5] Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
Buck, J
Sinclair, ML
Schapal, L
Cann, MJ
Levin, LR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) : 79 - 84
[6] Buck J, 2002, METHOD ENZYMOL, V345, P95
[7] Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
Chen, YQ
Cann, MJ
Litvin, TN
Iourgenko, V
Sinclair, ML
Levin, LR
Buck, J
[J]. SCIENCE, 2000, 289 (5479) : 625 - 628
[8] AKAPs: from structure to function
Colledge, M
Scott, JD
[J]. TRENDS IN CELL BIOLOGY, 1999, 9 (06) : 216 - 221
[9] COTE CH, 1997, AM J PHYSIOL-REG I, V273, pR1211
[10] Cyclic AMP signaling and gene regulation
Daniel, PB
Walker, WH
Habener, JF
[J]. ANNUAL REVIEW OF NUTRITION, 1998, 18 : 353 - 383

← 1 2 3 4 5 6 →