The biologically active isomers of conjugated linoleic acid

被引:952
作者
Pariza, MW [1 ]
Park, Y
Cook, ME
机构
[1] Univ Wisconsin, Food Res Inst, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA
[2] Univ Wisconsin, Food Res Inst, Dept Anim Sci, Madison, WI 53706 USA
关键词
adipocytes; skeletal muscle; lipoprotein lipase; stearoyl-CoA desaturase; 3T3-L1; Hep-G2; carcinogenesis; feed efficiency; growth; body composition; conjugated nonadecadienoic acid; immune function; cytokines; TNF-alpha; IL-1; PPAR;
D O I
10.1016/S0163-7827(01)00008-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Numerous physiological effects are attributed to conjugated linoleic acid (CLA). The purpose of this presentation is to consider these effects with respect to the cis-9,trans-11 and trans-10,cis-12 CLA isomers. We review previously published data and present new findings that relate to underlying biochemical mechanisms of action. Both isomers are natural products. The cis-9,trans-11 isomer is the principal dietary form of CLA. but the concentrations of this isomer and the trans-10,cis-12 isomer in dairy products or beef vary depending on the diet fed to cows or steers. respectively. The trans-10,cis-12 CLA isomer exerts specific effects on adipocytes, in particular reducing the uptake of lipid by inhibiting the activities of lipoprotein lipase and stearoyl-CoA desaturase. The trans-10,cis-12 CLA isomer also affects lipid metabolism in cultured Hep-GZ human liver cells, whereas both the cis-9,trans-11 and trans-10,cis-12 CLA isomers appear to be active in inhibiting carcinogenesis in animal models. We present new findings indicating that the cis-9,trans-11 CLA isomer enhances growth and probably feed efficiency in young rodents. Accordingly, the effects of CLA on body composition (induced by trans-10,cis-12 CLA) and growth/feed efficiency (induced by cis-9,trans-11 CLA) appear to be due to separate biochemical mechanisms. We also show that a 19-carbon CLA cognate (conjugated nonadecadienoic acid, CNA) inhibits lipoprotein lipase activity as effectively as CLA in cultured 3T3-L1 adipocytes. Presumably, CNA is metabolized differently than the 18-carbon CLA isomers. so this finding indicates direct activity of the administered compound as opposed to acting via a metabolite. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:283 / 298
页数:16
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