Regulation of mineralocorticoid biosynthesis by calcium and the StAR protein

被引：14

作者：

Cherradi, N ^{[1
]}

Brandenburger, Y

Rossier, MF

Capponi, AM

机构：

[1] Univ Hosp, Div Endocrinol & Diabetol, CH-1211 Geneva 14, Switzerland

[2] Univ Hosp, Clin Chem Lab, CH-1211 Geneva, Switzerland

来源：

ENDOCRINE RESEARCH | 1998年 / 24卷 / 3-4期

关键词：

D O I：

10.3109/07435809809032615

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In adrenal zona glomerulosa cells, the calcium messenger system is the major signaling mechanism activated by physiological stimulators of aldosterone production. We present here evidence for a dual site of action of the calcium signal: 1) Calcium influx into the mitochondrion is a prerequisite to the activation of steroidogenesis. This calcium entry leads to a rise in mitochondrial calcium concentration and to an increase in intramitochondrial cholesterol transfer and Steroidogenic Acute Regulatory (StAR) protein accumulation in inner mitochondrial membranes. 2) Calcium also exerts a genomic regulatory effect by activating transcription of the StAR gene.

引用

页码：355 / 362

页数：8

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