Using Prothrombin Complex Concentrates to Rapidly Reverse Oral Anticoagulant Effects

被引：18

作者：

Dager, William E. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Davis, Med Ctr, Sacramento, CA 95817 USA

[2] Univ Calif San Francisco, Sch Pharm, San Francisco, CA 94143 USA

[3] Univ Calif Davis, Sch Med, Sacramento, CA 95817 USA

[4] Touro Coll, Sch Pharm, Vallejo, CA USA

来源：

ANNALS OF PHARMACOTHERAPY | 2011年 / 45卷 / 7-8期

关键词：

anticoagulation; prothrombin complex concentrates; reversal; trauma; warfarin; FRESH-FROZEN PLASMA; VITAMIN-K; WARFARIN; COAGULOPATHY; GUIDELINES; EFFICACY; SAFETY; THERAPY; SURGERY;

D O I：

10.1345/aph.1Q288

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Warfarin is a commonly prescribed anticoagulant that may, in selected situations, require rapid reversal of its effects. Several approaches to achieve reversal have been explored, including the administration of prothrombin complex concentrates (PCCs), Many factors can influence determination of an appropriate PCC dose and the resulting effects. Considerations on the use of PCC products to expedite the reversal of warfarin are described.

引用

收藏

页码：1016 / 1020

页数：5

相关论文

共 36 条

[1] Pharmacology and management of the vitamin K antagonists [J].

Ansell, Jack ;

Hirsh, Jack ;

Hylek, Elaine ;

Jacobson, Alan ;

Crowther, Mark ;

Palareti, Gualtiero .

CHEST, 2008, 133 (06) :160S-198S

[2] Guidelines on oral anticoagulation (warfarin): third edition - 2005 update [J].

Baglin, TP ;

Keeling, DM ;

Watson, HG .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 132 (03) :277-285

[3] Warfarin reversal: consensus guidelines on behalf of the Australasian Society of Thrombosis and Haemostasis [J].

Baker, RI ;

Coughlin, PB ;

Gallus, AS ;

Harper, PL ;

Salem, HH .

MEDICAL JOURNAL OF AUSTRALIA, 2004, 181 (09) :492-+

[4] Coagulopathy and inhospital deaths in patients with acute subdural hematoma [J].

Bershad, Eric M. ;

Farhadi, Saeid ;

Suri, M. Fareed K. ;

Feen, Eliahu S. ;

Hernandez, Olga H. ;

Selman, Warren R. ;

Suarez, Jose I. .

JOURNAL OF NEUROSURGERY, 2008, 109 (04) :664-669

[5] Prothrombin Complex Concentrates for Oral Anticoagulant Therapy-Related Intracranial Hemorrhage: A Review of the Literature [J].

Bershad, Eric M. ;

Suarez, Jose I. .

NEUROCRITICAL CARE, 2010, 12 (03) :403-413

[6] Prothrombin Complex Concentrate Versus Standard Therapies for INR Reversal in Trauma Patients Receiving Warfarin [J].

Chapman, Scott A. ;

Irwin, Eric D. ;

Beal, Alan L. ;

Kulinski, Nichole M. ;

Hutson, Katherine E. ;

Thorson, Melissa A. L. .

ANNALS OF PHARMACOTHERAPY, 2011, 45 (7-8) :869-875

[7] Rapid reversal of coagulopathy in warfarin-related intracranial haemorrhages with prothrombin complex concentrates [J].

Chong, C. T. ;

Lew, T. W. K. ;

Kuperan, P. ;

Tan, J. J. E. ;

Tan, H. L. ;

Kwek, T. K. .

ANAESTHESIA AND INTENSIVE CARE, 2010, 38 (03) :474-480

[8] Prothrombinex use for the reversal of warfarin: is fresh frozen plasma needed? [J].

Crawford, JH ;

Augustson, BM .

MEDICAL JOURNAL OF AUSTRALIA, 2006, 184 (07) :365-366

[9] Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized study [J].

Demeyere, R. ;

Gillardin, S. ;

Arnout, J. ;

Strengers, P. F. W. .

VOX SANGUINIS, 2010, 99 (03) :251-260

[10] Reversal of the inhibitory effect of Fondaparinux on Thrombin generation by rFVIIa, aCCP and PCC [J].

Desmurs-Clavel, H. ;

Huchon, C. ;

Chatard, B. ;

Negrier, C. ;

Dargaud, Y. .

THROMBOSIS RESEARCH, 2009, 123 (05) :796-798

← 1 2 3 4 →