Visceral leishmaniasis: immunology and prospects for a vaccine

被引：80

作者：

Kaye, P. M. ^{[1
,2
]}

Aebischer, T. ^{[3
]}

机构：

[1] Univ York, Ctr Immunol & Infect, Hull York Med Sch, York YO10 5YW, N Yorkshire, England

[2] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England

[3] Robert Koch Inst, D-13353 Berlin, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 10期

关键词：

Immunology; vaccine; visceral leishmaniasis; TRANSMISSION-BLOCKING VACCINE; T-CELLS; CUTANEOUS LEISHMANIASIS; DONOVANI INFECTION; MAJOR INFECTION; MEGLUMINE ANTIMONIATE; CANINE LEISHMANIASIS; ANTIGEN PRESENTATION; PROTECTIVE IMMUNITY; EXPRESSION CLONING;

D O I：

10.1111/j.1469-0691.2011.03610.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Human visceral leishmaniasis (HVL) is the most severe clinical form of a spectrum of neglected tropical diseases caused by protozoan parasites of the genus Leishmania. Caused mainly by L. donovani and L. infantum/chagasi, HVL accounts for more than 50 000 deaths every year. Drug therapy is available but costly, and resistance against several drug classes has evolved. Here, we review our current understanding of the immunology of HVL and approaches to and the status of vaccine development against this disease.

引用

页码：1462 / 1470

页数：9

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