Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily
Apoptosis of cells must be regulated both positively and negatively in response to a variety of stimuli in the body. Various environmental stresses are known to initiate apoptosis via differential signal transduction cascades. However, induction of signals that may inhibit apoptosis is poorly understood, although a number of intracellular molecules that mediate inhibition of apoptosis have been identified. Here we present a novel murine macrophage-specific 54-kD secreted protein which inhibits apoptosis (termed AIM, for apoptosis inhibitor expressed by macrophages). AIM belongs to the macrophage scavenger receptor cysteine-rich domain superfamily (SRCR-SF), members of which share a highly homologous conserved cysteine-rich domain. In AIM-deficient mice, the thymocyte numbers were diminished to half those in wild-type mice, and CD4/CD8 double-positive (DP) thymocytes were strikingly more susceptible to apoptosis induced by both dexamethasone and irradiation in vivo. Recombinant AIM protein significantly inhibited cell death of DP thymocytes in response to a variety of stimuli in vitro. These results indicate that in the thymus, AIM functions in trans to induce resistance to apoptosis within DP cells, and thus supports the viability of DP thymocytes before thymic selection.
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
Aliprantis, AO
DiezRoux, G
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
DiezRoux, G
Mulder, LCF
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
Mulder, LCF
Zychlinsky, A
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
Zychlinsky, A
Lang, RA
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA
Chao, DT
Korsmeyer, SJ
论文数: 0引用数: 0
h-index: 0
机构:Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
Aliprantis, AO
DiezRoux, G
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
DiezRoux, G
Mulder, LCF
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
Mulder, LCF
Zychlinsky, A
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
Zychlinsky, A
Lang, RA
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST BIOMOL MED, DEPT PATHOL & MICROBIOL, NEW YORK, NY 10016 USA
机构:
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USAWashington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA
Chao, DT
Korsmeyer, SJ
论文数: 0引用数: 0
h-index: 0
机构:Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Mol Oncol, St Louis, MO 63110 USA