Synthesis of new artemisinin-derived dimers by self-cross-metathesis reaction

被引：31

作者：

Grellepois, F ^{[1
]}

Crousse, B ^{[1
]}

Bonnet-Delpon, D ^{[1
]}

Bégué, JP ^{[1
]}

机构：

[1] CNRS, BIOCIS, Fac Pharm Paris 11, F-92296 Chatenay Malabry, France

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 23期

关键词：

D O I：

10.1021/ol052056+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New artemisinin-derived dimers, fluorinated or not, have been prepared by a self-cross metathesis reaction in the presence of first- or second-generation ruthenium catalysts without degradation of the endoperoxide bridge and with a good EIZ selectivity (up to 100:0)

引用

页码：5219 / 5222

页数：4

共 46 条

[1]

ABDOUABDELLAH A, 1996, BIOORG MED CHEM LETT, V6, P2717

[2] Artemisinin-derived sesquiterpene lactones as potential antitumour compounds: Cytotoxic action against bone marrow and tumour cells [J].

Beekman, AC ;

Wierenga, PK ;

Woerdenbag, HJ ;

Van Uden, W ;

Pras, N ;

Konings, AWT ;

El-Feraly, FS ;

Galal, AM ;

Wikstrom, HV .

PLANTA MEDICA, 1998, 64 (07) :615-619

[3] Stereochemistry-dependent cytotoxicity of some artemisinin derivatives [J].

Beekman, AC ;

Barentsen, ARW ;

Woerdenbag, HJ ;

VanUden, W ;

Pras, N ;

Konings, AWT ;

ElFeraly, FS ;

Galal, AM ;

Wikstrom, HV .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (04) :325-330

[4]

Beekman AC, 1996, PHYTOTHER RES, V10, P140, DOI 10.1002/(SICI)1099-1573(199603)10:2&lt

[5]

140::AID-PTR792&gt

[6]

3.0.CO

[7]

2-D

[8] SOME PRACTICAL CONSIDERATIONS AND APPLICATIONS OF THE NATIONAL-CANCER-INSTITUTE IN-VITRO ANTICANCER DRUG DISCOVERY SCREEN [J].

BOYD, MR ;

PAULI, KD .

DRUG DEVELOPMENT RESEARCH, 1995, 34 (02) :91-109

[9]

BREITMAIER E, 2002, STRUCTURE ELUCIDATIO, P48

[10] Recent developments in olefin cross-metathesis [J].

Connon, SJ ;

Blechert, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (17) :1900-1923

← 1 2 3 4 5 →