The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

被引：65

作者：

Duncan, G ^{[1
]}

McCormick, C ^{[1
]}

Tufaro, F ^{[1
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2001年 / 108卷 / 04期

关键词：

D O I：

10.1172/JCI200113737

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：511 / 516

页数：6

共 46 条

[1] CLONING OF THE PUTATIVE TUMOR-SUPPRESSOR GENE FOR HEREDITARY MULTIPLE EXOSTOSES (EXT1) [J].

AHN, J ;

JOSEFLUDECKE, H ;

LINDOW, S ;

HORTON, WA ;

LEE, B ;

WAGNER, MJ ;

HORSTHEMKE, B ;

WELLS, DE .

NATURE GENETICS, 1995, 11 (02) :137-143

[2] Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion [J].

Bellaiche, Y ;

The, I ;

Perrimon, N .

NATURE, 1998, 394 (6688) :85-88

[3] Cytoskeletal abnormalities in chondrocytes with EXT1 and EXT2 mutations [J].

Bernard, MA ;

Hogue, DA ;

Cole, WG ;

Sanford, T ;

Snuggs, MB ;

Montufar-Solis, D ;

Duke, PJ ;

Carson, DD ;

Scott, A ;

Van Winkle, WB ;

Hecht, JT .

JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (03) :442-450

[4]

BERNFIELD M, ANN REV BIOCH, V68, P729

[5] Etiological point mutations in the hereditary multiple exostoses gene EXT1:: A functional analysis of heparan sulfate polymerase activity [J].

Cheung, PK ;

McCormick, C ;

Crawford, BE ;

Esko, JD ;

Tufaro, F ;

Duncan, G .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (01) :55-66

[6] The structure of the human multiple Exostoses 2 gene and characterization of homologs in mouse and Caenorhabditis elegans [J].

Clines, GA ;

Ashley, JA ;

Shah, S ;

Lovett, M .

GENOME RESEARCH, 1997, 7 (04) :359-367

[7] Chondrocyte apoptosis in development, aging and disease [J].

Horton, WE ;

Feng, LX ;

Adams, C .

MATRIX BIOLOGY, 1998, 17 (02) :107-115

[8] Transducing hedgehog: the story so far [J].

Ingham, PW .

EMBO JOURNAL, 1998, 17 (13) :3505-3511

[9] Matrix proteoglycans: From molecular design to cellular function [J].

Iozzo, RV .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :609-652

[10] Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4-N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis [J].

Kim, BT ;

Kitagawa, H ;

Tamura, J ;

Saito, T ;

Kusche-Gullberg, M ;

Lindahl, U ;

Sugahara, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7176-7181

← 1 2 3 4 5 →