Natural presence of NS3 protease R155K hepatitis C virus variants with decreased sensitivity to protease inhibitors

被引：5

作者：

Colson, Philippe ^{[1
,2
]}

Purgus, Raj ^{[3
]}

Borentain, Patrick ^{[4
]}

Gerolami, Rene ^{[4
]}

机构：

[1] CHU Timone, 264 Rue St Pierre, F-13385 Marseille 05, France

[2] Aix Marseille Univ, URMITE, CNRS, Fac Med & Pharm,UMR 6236,IRD 198, F-13385 Marseille 05, France

[3] Aix Marseille Univ, Assistance Publ Hop Marseille, Ctr Nephrol & Transplantat Renale, Hop Concept, F-13385 Marseille 05, France

[4] Ctr Hosp Univ Concept, Serv Hepatogastro Enterol, F-13385 Marseille 05, France

来源：

JOURNAL OF CLINICAL VIROLOGY | 2012年 / 53卷 / 02期

关键词：

Hepatitis C virus; Antiviral therapy; NS3 protease inhibitors; Genotypic resistance; R155K mutation; Natural resistance; RESISTANCE; INFECTION;

D O I：

10.1016/j.jcv.2011.10.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

引用

页码：178 / 180

页数：3

共 5 条

[1] Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3•4A protease inhibitors in treatment-naive subjects [J].

Bartels, Doug J. ;

Zhou, Yi ;

Zhang, Eileen Z. ;

Marcial, Michelle ;

Byrn, Randal A. ;

Pfeiffer, Thomas ;

Tigges, Ann M. ;

Adiwijaya, Bambang S. ;

Lin, Chao ;

Kwong, Ann D. ;

Kieffer, Tara L. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (06) :800-807

[2] Two Years' Persistence of Naturally Present Substitution R155K Within Hepatitis C Virus NS3 Protease in the Absence of Protease Inhibitor-based Therapy [J].

Colson, Philippe ;

Gerolami, Rene .

JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (09) :1341-1341

[3]

López-Labrador FX, 2008, ANTIVIR THER, V13, P481

[4] Resistance to Direct Antiviral Agents in Patients With Hepatitis C Virus Infection [J].

Sarrazin, Christoph ;

Zeuzem, Stefan .

GASTROENTEROLOGY, 2010, 138 (02) :447-462

[5] Antiretroviral Treatment of Adult HIV Infection 2010 Recommendations of the International AIDS Society-USA Panel [J].

Thompson, Melanie A. ;

Aberg, Judith A. ;

Cahn, Pedro ;

Montaner, Julio S. G. ;

Rizzardini, Giuliano ;

Telenti, Amalio ;

Gatell, Jose M. ;

Guenthard, Huldrych F. ;

Hammer, Scott M. ;

Hirsch, Martin S. ;

Jacobsen, Donna M. ;

Reiss, Peter ;

Richman, Douglas D. ;

Volberding, Paul A. ;

Yeni, Patrick ;

Schooley, Robert T. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (03) :321-333

← 1 →