Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts

被引：138

作者：

Jevon, M

Guo, CB

Ma, BC

Mordan, N

Nair, SP

Harris, M

Henderson, B

Bentley, G

Meghji, S

机构：

[1] UCL, Dept Oral & Maxillofacial Surg, Maxillofacial Surg Res Unit, Eastman Dent Inst, London WC1X 8LD, England

[2] UCL, Electron Microscopy Unit, Eastman Dent Inst, London WC1X 8LD, England

[3] Royal Natl Orthopaed Hosp Trust, Inst Orthopaed, Stanmore, Middx, England

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 05期

关键词：

D O I：

10.1128/IAI.67.5.2677-2681.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.

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页码：2677 / 2681

页数：5

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