LipA, a Tyrosine and Lipid Phosphatase Involved in the Virulence of Listeria monocytogenes

被引：28

作者：

Kastner, Renate ^{[3
]}

Dussurget, Olivier ^{[2
,4
]}

Archambaud, Cristel ^{[2
]}

Kernbauer, Elisabeth ^{[3
]}

Soulat, Didier ^{[3
]}

Cossart, Pascale ^{[1
,2
]}

Decker, Thomas ^{[3
]}

机构：

[1] Inst Pasteur, INSERM 4604, Unite Interact Bacteries Cellules, INRA USC2020, F-75015 Paris, France

[2] Inserm U604, F-75015 Paris, France

[3] Univ Vienna, Max F Perutz Labs, Dept Microbiol Immunobiol & Genet, A-1030 Vienna, Austria

[4] Univ Paris 07, F-75013 Paris, France

来源：

INFECTION AND IMMUNITY | 2011年 / 79卷 / 06期

基金：

奥地利科学基金会;

关键词：

IN-VITRO TRANSCRIPTION; MYCOBACTERIUM-TUBERCULOSIS; POSTTRANSLATIONAL MODIFICATIONS; PHOSPHOINOSITIDE METABOLISM; IMMUNE-RESPONSES; III SECRETION; HOST-CELLS; GENES; PHOSPHORYLATION; PATHOGENESIS;

D O I：

10.1128/IAI.05073-11

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Intracellular bacterial pathogens manipulate host cell functions by producing enzymes that stimulate or antagonize signal transduction. The Listeria monocytogenes genome contains a gene, lmo1800, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that the lmo1800-encoded protein LipA is secreted by Listeria and displays tyrosine as well as lipid phosphatase activity in vitro. Bacteria lacking LipA are severely attenuated in virulence in vivo, thus revealing a so-far-undescribed enzymatic activity involved in Listeria infection.

引用

收藏

页码：2489 / 2498

页数：10

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