Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

被引:461
作者
Bays, H
Mandarino, L
DeFronzo, RA
机构
[1] Univ Texas, Hlth Sci Ctr, Diabet Div, San Antonio, TX 78229 USA
[2] Louisville Metab & Atherosclerosis Res Ctr, Louisville, KY 40213 USA
关键词
D O I
10.1210/jc.2003-030723
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:463 / 478
页数:16
相关论文
共 328 条
  • [1] ACUTE AND CHRONIC RESPONSES OF SKELETAL-MUSCLE TO ENDURANCE AND SPRINT EXERCISE - A REVIEW
    ABERNETHY, PJ
    THAYER, R
    TAYLOR, AW
    [J]. SPORTS MEDICINE, 1990, 10 (06) : 365 - 389
  • [2] Activators of peroxisome proliferator-activated receptor γ have depot-specific effects on human preadipocyte differentiation
    Adams, M
    Montague, CT
    Prins, JB
    Holder, JC
    Smith, SA
    Sanders, L
    Digby, JE
    Sewter, CP
    Lazar, MA
    Chatterjee, VKK
    O'Rahilly, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12) : 3149 - 3153
  • [3] Albu JB, 2000, ANN NY ACAD SCI, V904, P491
  • [4] Plasminogen activator inhibitor 1, transforming growth factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity
    Alessi, MC
    Bastelica, D
    Morange, P
    Berthet, B
    Leduc, I
    Verdier, M
    Geel, O
    Juhan-Vague, I
    [J]. DIABETES, 2000, 49 (08) : 1374 - 1380
  • [5] Production of plasminogen activator inhibitor 1 by human adipose tissue - Possible link between visceral fat accumulation and vascular disease
    Alessi, MC
    Peiretti, F
    Morange, P
    Henry, M
    Nalbone, G
    JuhanVague, I
    [J]. DIABETES, 1997, 46 (05) : 860 - 867
  • [6] Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes
    Arioglu, E
    Duncan-Morin, J
    Sebring, N
    Rother, KI
    Gottlieb, N
    Lieberman, J
    Herion, D
    Kleiner, DE
    Reynolds, J
    Premkumar, A
    Sumner, AE
    Hoofnagle, J
    Reitman, ML
    Taylor, SI
    [J]. ANNALS OF INTERNAL MEDICINE, 2000, 133 (04) : 263 - 274
  • [7] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    Arita, Y
    Kihara, S
    Ouchi, N
    Takahashi, M
    Maeda, K
    Miyagawa, J
    Hotta, K
    Shimomura, I
    Nakamura, T
    Miyaoka, K
    Kuriyama, H
    Nishida, M
    Yamashita, S
    Okubo, K
    Matsubara, K
    Muraguchi, M
    Ohmoto, Y
    Funahashi, T
    Matsuzawa, Y
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) : 79 - 83
  • [8] Arner P, 2001, BIOCHEM SOC T, V29, P72, DOI 10.1042/bst0290072
  • [9] Regional adipocity in man
    Arner, P
    [J]. JOURNAL OF ENDOCRINOLOGY, 1997, 155 (02) : 191 - 192
  • [10] Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes - A 6-month randomized placebo-controlled dose-response study
    Aronoff, S
    Rosenblatt, S
    Braithwaite, S
    Egan, JW
    Mathisen, AL
    Schneider, RL
    [J]. DIABETES CARE, 2000, 23 (11) : 1605 - 1611