Chitosan Oligosaccharide-Stabilized Ferrimagnetic Iron Oxide Nanocubes for Magnetically Modulated Cancer Hyperthermia

被引：266

作者：

Bae, Ki Hyun ^{[3
]}

Park, Mihyun ^{[1
,2
]}

Do, Min Jae

Lee, Nohyun ^{[1
,2
]}

Ryu, Ji Hyun ^{[4
]}

Kim, Gun Woo ^{[5
]}

Kim, CheolGi ^{[5
]}

Park, Tae Gwan ^{[3
,4
]}

Hyeon, Taeghwan ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

[2] Seoul Natl Univ, World Class Univ Program Chem Convergence Energy, Seoul 151744, South Korea

[3] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Taejon 305701, South Korea

[5] Chungnam Natl Univ, Dept Mat Sci & Engn, Taejon 305764, South Korea

来源：

ACS NANO | 2012年 / 6卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

chitosan; magnetite; magnetic modulation; nanocube; cancer therapy; hyperthermia; MRI CONTRAST; NANOPARTICLES; FUNCTIONALIZATION; THERAPY; RELEASE; BILAYER; SHELL;

D O I：

10.1021/nn301046w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.

引用

页码：5266 / 5273

页数：8

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