Synthesis and biological evaluation of 14-alkoxymorphinans -: Part 15 -: Novel δ opioid receptor antagonists with high affinity and selectivity in the 14-alkoxy-substituted indolomorphinan series

被引：18

作者：

Schmidhammer, H

Krassnig, R

Greiner, E

Schütz, J

White, A

Berzetei-Gurske, IP

机构：

[1] Univ Innsbruck, Inst Pharmaceut Chem, A-6020 Innsbruck, Austria

[2] SRI Int, Div Pharmaceut, Menlo Pk, CA 94025 USA

来源：

HELVETICA CHIMICA ACTA | 1998年 / 81卷 / 06期

关键词：

D O I：

10.1002/hlca.19980810519

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The indolomorphinans 4-7 were prepared from their corresponding morphinan-6-one derivatives 8-11 via Fischer indole synthesis. Compounds 4 and 5 exhibited higher antagonist potency at delta opioid receptors in the mouse vas deferens preparation than the reference drug HS 378 (2), while compounds 6 and 7 were less potent.

引用

页码：1064 / 1069

页数：6

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