HFE genotype and transferrin saturation in the United States

被引：17

作者：

Cogswell, ME

Gallagher, ML

Steinberg, KK

Caudill, SP

Looker, AC

Bowman, BA

Gunter, EW

Franks, AL

Satten, GA

Khoury, MJ

Grummer-Strawn, LM

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Nutr & Phys Act, Atlanta, GA 30341 USA

[2] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Chamblee, GA USA

[3] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Examinat Stat, Hyattsville, MD 20782 USA

[4] Ctr Dis Control & Prevent, Div Diabetes Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA

[5] Ctr Dis Control & Prevent, Epidemiol Program Off, Atlanta, GA USA

[6] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Off Genet & Dis Prevent, Chamblee, GA USA

来源：

GENETICS IN MEDICINE | 2003年 / 5卷 / 04期

关键词：

hemochromatosis; HFE genotype; transferrin saturation; Mexican-Americans; non-Hispanic blacks;

D O I：

10.1097/01.GIM.0000076976.08421.AB

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population. Methods: 5171 participants from the Third National Health and Nutrition Examination Survey, 1992 to 1994. Results: 77.1% (95% confidence interval [CI], 2.3, 95.1) of men and 51.9% (95% CI, 0, 84.2) of women with C282Y homozygosity had high TS. The associations of H63D homozygosity with high TS were stronger in people aged 50 years or older than in younger persons. Among Mexican-Americans, simple H63D heterozygosity was associated with high TS. Conclusions: The associations between HFE genotype and high TS may vary by sex, age, and ethnic group.

引用

页码：304 / 310

页数：7

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