Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism

被引：156

作者：

Tang, H ^{[1
]}

McLachlan, A ^{[1
]}

机构：

[1] Scripps Res Inst, Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 04期

关键词：

D O I：

10.1073/pnas.041479698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hepatotropism is a prominent feature of hepatitis B virus (HBV) infection. Cell lines of nonhepatic origin do not independently support HBV replication. Here, we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor cu plus peroxisome proliferator-activated receptor or, support HBV replication in nonhepatic cells by controlling pregenomic RNA synthesis, indicating these liver-enriched transcription factors control a unique molecular switch restricting viral tropism. In contrast, hepatocyte nuclear factor 3 antagonizes nuclear hormone receptor-mediated viral replication, demonstrating distinct regulatory roles for these liver-enriched transcription factors.

引用

页码：1841 / 1846

页数：6

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