The LDL receptor gene family: signaling functions during development

被引：66

作者：

Howell, BW ^{[1
]}

Herz, L

机构：

[1] NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(00)00176-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The traditional views regarding the biological functions of the low-density lipoprotein (LDL) receptor gene family have been revisited recently with new evidence that at least some of the members of this receptor family act as signal-transduction molecules. Known for their role in endocytosis, particularly of their namesake the LDLs, and for their role in the prevention of atherosclerosis, these receptors belong to an ancient family with numerous ligands, effector molecules and functions. Recent evidence implicates this family of receptors in diverse signaling pathways, long-term potentiation and neuronal degeneration.

引用

收藏

页码：74 / 81

页数：8

相关论文

共 47 条

[1]

Distinct functions of α3 and αv integrin receptors in neuronal migration and laminar organization of the cerebral cortex [J].

Anton, ES ;

Kreidberg, JA ;

Rakic, P .

NEURON, 1999, 22 (02) :277-289

[2]

A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

SCIENCE, 1986, 232 (4746) :34-47

[3]

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality [J].

Chae, T ;

Kwon, YT ;

Bronson, R ;

Dikkes, P ;

Li, E ;

Tsai, LH .

NEURON, 1997, 18 (01) :29-42

[4]

CHEN WJ, 1990, J BIOL CHEM, V265, P3116

[5]

Reelin is a ligand for lipoprotein receptors [J].

D'Arcangelo, G ;

Homayouni, R ;

Keshvara, L ;

Rice, DS ;

Sheldon, M ;

Curran, T .

NEURON, 1999, 24 (02) :471-479

[6]

ACID-DEPENDENT LIGAND DISSOCIATION AND RECYCLING OF LDL RECEPTOR MEDIATED BY GROWTH-FACTOR HOMOLOGY REGION [J].

DAVIS, CG ;

GOLDSTEIN, JL ;

SUDHOF, TC ;

ANDERSON, RGW ;

RUSSELL, DW ;

BROWN, MS .

NATURE, 1987, 326 (6115) :760-765

[7]

Reelin binds α3β1 integrin and inhibits neuronal migration [J].

Dulabon, L ;

Olson, EC ;

Taglienti, MG ;

Eisenhuth, S ;

McGrath, B ;

Walsh, CA ;

Kreidberg, JA ;

Anton, ES .

NEURON, 2000, 27 (01) :33-44

[8]

Cholesterol metabolism and embryogenesis [J].

Farese, RV ;

Herz, J .

TRENDS IN GENETICS, 1998, 14 (03) :115-120

[9]

Gilmore EC, 1998, J NEUROSCI, V18, P6370

[10]

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction [J].

Gotthardt, M ;

Trommsdorff, M ;

Nevitt, MF ;

Shelton, J ;

Richardson, JA ;

Stockinger, W ;

Nimpf, J ;

Herz, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25616-25624

← 1 2 3 4 5 →