Role of the basolateral nucleus of the amygdala in the formation of a phobia

被引：77

作者：

File, SE ^{[1
]}

Gonzalez, LE ^{[1
]}

Gallant, R ^{[1
]}

机构：

[1] UMDS, Guys Hosp, Psychopharmacol Res Unit, London SE1 9RT, England

来源：

NEUROPSYCHOPHARMACOLOGY | 1998年 / 19卷 / 05期

关键词：

anxiety; phobia; amygdala; benzodiazepines; emotional memory; plus-maze;

D O I：

10.1016/S0893-133X(98)00035-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Specific phobia is an anxiety disorder that does not respond to benzodiazepines. The elevated plus-maze test of anxiety is sensitive to benzodiazepines on trial 1, but during the first 5-min trial the nature of the anxiety generated changes to a specific fear of heights, and, as a result, on trial 2 the rats no longer respond to benzodiazepines. However, rats that received reversible bilateral lesions of the basolateral amygdala (by lidocaine injection) immediately after trial 1 responded with an anxiolytic response to chlordiazepoxide when tested 48 h later on trial 2. Those that received vehicle injections after trial 1 showed the usual lack of response to chlordiazepoxide on trial 2. Thus, the basolateral amygdala plays a crucial role in the consolidation of information that leads to the formation of a specific phobia and subsequent insensitivity to benzodiazapines. [Neuropsychopharmacology 19:397-405, 1998] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

引用

页码：397 / 405

页数：9

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