Variations and constant patterns in eukaryotic MDR enzymes -: Conclusions from novel structures and characterized genomes

被引：12

作者：

Jörnvall, H ^{[1
]}

Shafqat, J

Persson, B

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Stockholm Bioinformat Ctr, SE-17177 Stockholm, Sweden

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2001年 / 130卷 / 1-3期

关键词：

Medium-chain dehydrogenases/reductases (MDR); alcohol dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; completed eukaryotic genomes; ADH class emergence;

D O I：

10.1016/S0009-2797(00)00294-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases exhibit multiple forms through a number of gene duplications. A crucial duplication was the one leading from the glutathione-dependent formaldehyde dehydrogenase line to the liver alcohol dehydrogenase (ADH) lines of vertebrates, the first duplication of which can now be further positioned at early vertebrate times, Similarly, screening of MDR forms in recently completed eukaryotic genomes of Caenorbabditis elegans and Drosophila: melanogaster suggest that the MDR family may constitute a moderately sized protein family centered around a limited number of enzyme activities of five different structural types. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：491 / 498

页数：8

共 12 条

[1]

CANESTRO C, 2000, IN PRESS EUR J BIOCH

[2] FUNDAMENTAL MOLECULAR DIFFERENCES BETWEEN ALCOHOL-DEHYDROGENASE CLASSES [J].

DANIELSSON, O ;

ATRIAN, S ;

LUQUE, T ;

HJELMQVIST, L ;

GONZALEZDUARTE, R ;

JORNVALL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4980-4984

[3] Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis [J].

Duester, G .

BIOCHEMISTRY, 1996, 35 (38) :12221-12227

[4]

FERNANDEZ MR, 1995, FEBS LETT, V370, P23

[5]

Hjelmqvist L, 1995, METHODS IN PROTEIN STRUCTURE ANALYSIS, P419

[6]

JOHANSSON K, 2000, IN PRESS ADV EXP CEL

[7] SDR and MDR:: completed genome sequences show these protein families to be large, of old origin, and of complex nature [J].

Jörnvall, H ;

Höög, JO ;

Persson, B .

FEBS LETTERS, 1999, 445 (2-3) :261-264

[8] Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaryotic alcohol dehydrogenases - Primary structure, conformational modelling and functional correlations [J].

Norin, A ;

VanOphem, PW ;

Piersma, SR ;

Persson, B ;

Duine, JA ;

Jornvall, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 248 (02) :282-289

[9] A SUPER-FAMILY OF MEDIUM-CHAIN DEHYDROGENASES/REDUCTASES (MDR) - SUB-LINES INCLUDING XI-CRYSTALLIN, ALCOHOL AND POLYOL DEHYDROGENASES, QUINONE OXIDOREDUCTASES, ENOYL REDUCTASES, VAT-1 AND OTHER PROTEINS [J].

PERSSON, B ;

ZIGLER, JS ;

JORNVALL, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 226 (01) :15-22

[10] Pea formaldehyde-active class III alcohol dehydrogenase: Common derivation of the plant and animal forms but not of the corresponding ethanol-active forms (classes I and P) [J].

Shafqat, J ;

ElAhmad, M ;

Danielsson, O ;

Martinez, MC ;

Persson, B ;

Pares, X ;

Jornvall, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5595-5599

← 1 2 →