Development of software facilities to characterize regulatory binding motifs and application to Streptococcaceae

被引：6

作者：

Pons, Nicolas ^{[1
]}

Batto, Jean-Michel ^{[1
]}

Ehrlich, Stanislav Dusko ^{[1
]}

Renault, Pierre ^{[1
]}

机构：

[1] Inst Natl Rech Agronom, Genet Microbienne, FR-78352 Jouy En Josas, France

来源：

JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY | 2008年 / 14卷 / 1-3期

关键词：

streptococcaceae; regulatory network; regulatory motifs; comparative genomics; database;

D O I：

10.1159/000106084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gene expression regulation often involves the recognition of particular DNA or RNA sequences, called motifs. Detection and characterization of such motifs together with biological expertise allow to build gene expression regulatory maps that facilitate the comprehension of complex cellular processes. In this frame, we developed a software integrating relevant information for the detection and characterization of conserved motifs in genomic sequences. A relational database was built up to host data related to genomic information and transcriptional experiments. A user-friendly interface was designed to allow a convenient representation of these data and to run the detection motif program. A set of complementary utilities was also developed to improve the determination of motif consensus sequences and the detection of additional potential regulator targets in the genome. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：67 / 73

页数：7

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