PPAR-α effects on the heart and other vascular tissues

被引：78

作者：

Francis, GA ^{[1
]}

Annicotte, JS

Auwerx, J

机构：

[1] Univ Alberta, HMRC 328, Canadian Inst Hlth Res Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada

[2] Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada

[3] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2S2, Canada

[4] Univ Strasbourg 1, Inst Natl Sante & Rech Med, Ctr Natl Rech Sci, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2003年 / 285卷 / 01期

关键词：

atherosclerosis; fatty acid oxidation; lipoproteins; cholesterol; nuclear receptors; peroxisome proliferator-activated receptor-alpha; ATP-binding cassette transporter A1; fibrate; high-density lipoprotein;

D O I：

10.1152/ajpheart.01118.2002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptor (PPAR)-alpha is a member of a large nuclear receptor superfamily whose main role is to activate genes involved in fatty acid oxidation in the liver, heart, kidney, and skeletal muscle. While currently used mainly as hypolipidemic agents, the cardiac effects and anti-inflammatory actions of PPAR-alpha agonists in arterial wall cells suggest other potential cardioprotective and antiatherosclerotic effects of these agents. This review summarizes current knowledge regarding the effects of PPAR-alpha agonists on lipid and lipoprotein metabolism, the heart, and the vessel wall and introduces some of the insights gained in these areas from studying PPAR-alpha-deficient mice. The introduction of new and more potent PPAR-alpha agonists will provide important insights into the overall benefits of activating PPAR-alpha clinically for the treatment of dyslipidemia and prevention of vascular disease.

引用

页码：H1 / H9

页数：9

共 105 条

[1] Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-α activator [J].