The gallium-deferoxamine complex: Stability with different deferoxamine concentrations and incubation conditions

被引：20

作者：

Caraco, C

Aloj, L

Eckelman, WC

机构：

[1] NIH, Positron Emiss Tomog Dept, Ctr Clin, Bethesda, MD 20892 USA

[2] NIH, Dept Nucl Med, Ctr Clin, Bethesda, MD 20892 USA

来源：

APPLIED RADIATION AND ISOTOPES | 1998年 / 49卷 / 12期

关键词：

D O I：

10.1016/S0969-8043(97)10107-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Previous studies report that deferoxamine (DFO) binds metallic ions such as Fe3+, In3+ and Ga3+ with very high affinity. This property of DFO has been utilized to label DFO-coupled compounds with radiometals such as Ga-67 and In-111. We have studied the effect of low DFO concentrations and of different incubation conditions on the stability of the Ga-67-DFO complex. In our experience high (>5 mu M) DFO concentration appears to be critical in obtaining high radiochemical purity of such complexes. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1477 / 1479

页数：3

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