The Gli code: an information nexus regulating cell fate, stemness and cancer

被引：358

作者：

Ruiz i Altaba, Ariel ^{[1
]}

Mas, Christophe ^{[1
]}

Stecca, Barbara ^{[1
]}

机构：

[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CMU 8242, CH-1211 Geneva, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 09期

关键词：

D O I：

10.1016/j.tcb.2007.06.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates sternness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.

引用

页码：438 / 447

页数：10

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