Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms

被引：29

作者：

Yang, XL

Pratley, RE

Baier, LJ

Horikawa, Y

Bell, GI

Bogardus, C

Permana, PA

机构：

[1] NIDDKD, Clin Diabet & Nutr Sect, Pheonix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ 85016 USA

[2] Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Med & Human Genet, Chicago, IL 60637 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2001年 / 73卷 / 01期

关键词：

type; 2; diabetes; Pima Indians; Calpain-10; isoforms; skeletal muscle;

D O I：

10.1006/mgme.2001.3171

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The DNA polymorphism SNP-43 in the calpain-10 gene is associated with insulin resistance and reduced skeletal muscle transcript in Pima Indians. Alternative splicing generates transcript isoforms calpain-10a to -10h. We determined the contribution of calpain-10 mRNA isoforms to the decreased total skeletal muscle calpain-10 mRNA levels observed in the G/G homozygotes. The expression levels of the major isoforms, calpain-10a and -10f, were positively correlated with the total calpain-10 mRNA levels, indicating a cumulative effect. (C) 2001 Academic Press.

引用

页码：111 / 113

页数：3

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