Glial transporters for glutamate, glycine, and GABA III.: Glycine transporters

被引：53

作者：

Gadea, A

López-Colomé, AM

机构：

[1] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neurociencias, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City, DF, Mexico

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2001年 / 64卷 / 03期

关键词：

neurotransmitter uptake; neuron-glia interaction; second messengers; membrane protein; synaptic modulation;

D O I：

10.1002/jnr.1069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial cells possess transport systems for the three major amino acid neurotransmitters glutamate, gamma -aminobutyric acid (GABA) and glycine, involved in the arrest of neurotransmission mediated by these compounds. Two glycine transporters have been cloned: GLYT1, mainly expressed by glial cells and shown to colocalize with NMDA receptors, and GLYT2, exclusively expressed by neurons and colocalized with the inhibitory glycine receptors, The way in which the regulation of extracellular glycine concentration by glial glycine transporters affects physiological and pathological conditions is discussed. The presence, differential pharmacology and specific regulation of glycine transporters in glial cells strongly support an important role for glia in the modulation of both, excitatory and inhibitory neurotransmission. (C) 2001 Wiley-Liss, Inc.

引用

页码：218 / 222

页数：5

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