Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus

被引：134

作者：

Keating, FK ^{[1
]}

Sobel, BE ^{[1
]}

Schneider, DJ ^{[1
]}

机构：

[1] Univ Vermont, Dept Med, Burlington, VT USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 11期

关键词：

D O I：

10.1016/j.amjcard.2003.08.033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperglycemia has been linked to adverse outcomes after myocardial infarction. We characterized the effect of selected concentrations of glucose or mannitol on platelet function in whole blood samples from healthy volunteers and from patients with and without diabetes mellitus. Activation of platelet glycoprotein IIb/IIIa and P-selectin expression was increased similarly after addition of isosmotic concentrations of glucose and mannitol, suggesting that increased osmolarity associated with hyperglycemia increases platelet reactivity. (C) 2003 by Excerpta Medica, Inc.

引用

页码：1362 / 1365

页数：4

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