Report of an NIAID workshop on dengue animal models

被引：61

作者：

Cassetti, M. Cristina ^{[1
]}

Durbin, Anna ^{[2
]}

Harris, Eva ^{[3
]}

Rico-Hesse, Rebeca ^{[4
]}

Roehrig, John ^{[5
]}

Rothman, Alan ^{[6
]}

Whitehead, Stephen ^{[1
]}

Natarajan, Ramya ^{[1
]}

Laughlin, Catherine ^{[1
]}

机构：

[1] NIAID, Bethesda, MD 20892 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[3] Univ Calif Berkeley, Berkeley, CA 94720 USA

[4] SW Fdn Biomed Res, San Antonio, TX 78284 USA

[5] Ctr Dis Control, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA

[6] Univ Massachusetts, Sch Med, Worcester, MA USA

来源：

VACCINE | 2010年 / 28卷 / 26期

关键词：

Dengue; Animal; Models; CLINICAL LABORATORY RESPONSES; TYPE-4 VACCINE CANDIDATE; RHESUS-MONKEYS; MOUSE MODEL; VIRUS-INFECTION; MICE LACKING; ANTIBODY; PATHOGENESIS; REPLICATION; PROTECTION;

D O I：

10.1016/j.vaccine.2010.04.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dengue is a mosquito-borne viral disease of humans that has re-emerged in many parts of the world and has become an important international public health threat. Dengue incidence and geographical spread has dramatically increased in the last few decades and is now affecting most tropical and sub-tropical regions of the world. Despite extensive research efforts for several decades, no vaccines or therapeutics are currently available to prevent and treat dengue infections. One of the main obstacles to the development of countermeasures has been the lack of good animal models that recapitulate dengue pathogenesis in humans and reliably predict the safety and efficacy of countermeasures against dengue. In September 2008, the National Institute of Allergy and Infectious Diseases (NIAID) held a workshop to consider the current state-of-the-art developments in animal models for dengue and discuss strategies to accelerate progress in this field. This report summarizes the main discussions and recommendations that resulted from the meeting.

引用

页码：4229 / 4234

页数：6

共 44 条

[1] Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification [J].