Dextromethorphan alters methamphetamine self-administration in the rat

被引：16

作者：

Jun, JH ^{[1
]}

Schindler, CW ^{[1
]}

机构：

[1] NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2000年 / 67卷 / 03期

关键词：

dextromethorphan; methamphetamine; self-administration; food control; NMDA antagonist; rat;

D O I：

10.1016/S0091-3057(00)00317-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Various lines of evidence indicate that methamphetamine (METH) self-administration in rats is under dopaminergic control, and NMDA receptors have been shown to control the release of dopamine at its synapse. Consequently, the aim of this study was to observe the effects of dextromethorphan (DM), a non-competitive NMDA antagonist, in rats self-administering METH. The hypothesis was that acute pretreatment of DM (25 mg/kg) would alter response to METH. DM significantly altered self-administration by reducing the number of correct responses for three METH self-administration doses (0.05, 0.1, 0.25 mg/kg). The same pretreatment did not affect responding for food reward. These findings show that the DM was able to selectively alter METH self-administration. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：405 / 409

页数：5

共 28 条

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