Epac: a new cAMP target and new avenues in cAMP research

被引：397

作者：

Bos, JL

机构：

[1] Univ Med Ctr Utrecht, Dept Physiol Chem, NL-3584 CG Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Ctr Biomed Genet, NL-3584 CG Utrecht, Netherlands

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 09期

关键词：

D O I：

10.1038/nrm1197

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Five years ago, Epac - a guanine nucleotide exchange factor for the Ras-like small GTPases Rap1 and Rap2 - was found to be a new target of cyclic AMP, which opened up new avenues for cAMP research. Structural analysis of the cAMP-binding domains of Epac2 has identified a unifying mechanism for how cAMP activates proteins, and the design and synthesis of an Epac-specific cAMP analogue has paved the way for future discoveries.

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收藏

页码：733 / 738

页数：6

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