IgG subclasses of anti Saccharomyces cerevisiae antibody in inflammatory bowel disease

被引：12

作者：

Oshitani, N ^{[1
]}

Hato, F ^{[1
]}

Jinno, Y ^{[1
]}

Sawa, Y ^{[1
]}

Nakamura, S ^{[1
]}

Matsumoto, T ^{[1
]}

Seki, S ^{[1
]}

Kitagawa, S ^{[1
]}

Arakawa, T ^{[1
]}

机构：

[1] Osaka City Univ, Sch Med, Dept Internal Med 3, Abeno Ku, Osaka 5458585, Japan

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2001年 / 31卷 / 03期

关键词：

ASCA; Crohn's disease; immunoglobulin; Saccharomyces cerevisiae;

D O I：

10.1046/j.1365-2362.2001.00798.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Elevation of serum anti Saccharomyces cerevisiae antibody (ASCA) has been reported in patients with Crohn's disease. We analysed the subclasses of Immunoglobulin (Ig) G reaction in ASCA in sera from patients with inflammatory bowel disease, healthy controls, and patients with intestinal Behcet's disease. Materials and methods Serum samples were obtained from 29 patients with Crohn's disease, 30 patients with ulcerative colitis, 7 patients with intestinal Behcet's disease, and 12 healthy controls. Serum IgG subclasses IgG1, IgG2, IgG3, and IgG4 of ASCA were analysed using ELISA. Results IgG4 ASCA was significantly increased in patients with inflammatory bowel disease. In patients with intestinal Behcet's disease, IgG1, IgG3, and IgG4 ASCA were increased. Conclusions Differential responses, in terms of subclasses in ASCA, were found in patients with inflammatory bowel disease and patients with intestinal Behcet's disease, which may represent different pathophysiologies of these intestinal inflammatory diseases.

引用

页码：221 / 225

页数：5

共 29 条

[1] Immunoglobulin G subclass distribution of anti-endothelial cell antibodies (AECA) in patients with ulcerative colitis or Crohn's disease [J].

Aldebert, D ;

Masy, E ;

Reumaux, D ;

Lion, G ;

Colombel, JF ;

Duthilleul, P .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (11) :2350-2355

[2] Importance of antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and ulcerative colitis: Prevalence, titre, and IgG subclass [J].

Bansi, DS ;

Fleming, KA ;

Chapman, RW .

GUT, 1996, 38 (03) :384-389

[3] THE EFFECT OF DIETARY YEAST ON THE ACTIVITY OF STABLE CHRONIC CROHNS-DISEASE [J].

BARCLAY, GR ;

MCKENZIE, H ;

PENNINGTON, J ;

PARRATT, D ;

PENNINGTON, CR .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1992, 27 (03) :196-200

[4] SERUM ANTIBODIES REACTIVE WITH SACCHAROMYCES-CEREVISIAE IN INFLAMMATORY BOWEL-DISEASE - IS IGA ANTIBODY A MARKER FOR CROHNS-DISEASE [J].

BARNES, RMR ;

ALLAN, S ;

TAYLORROBINSON, CH ;

FINN, R ;

JOHNSON, PM .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1990, 92 (01) :9-15

[5] HUMAN-SERUM ANTIBODIES REACTIVE WITH DIETARY PROTEINS - IGG SUBCLASS DISTRIBUTION [J].

BARNES, RMR ;

JOHNSON, PM ;

HARVEY, MM ;

BLEARS, J ;

FINN, R .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1988, 87 (02) :184-188

[6] PRODUCTION OF IMMUNOGLOBULIN-G AND G1 ANTIBODIES TO CYTOSKELETAL PROTEIN BY LAMINA PROPRIA CELLS IN ULCERATIVE-COLITIS [J].

BIANCONE, L ;

MANDAL, A ;

YANG, H ;

DASGUPTA, T ;

PAOLUZI, AO ;

MARCHEGGIANO, A ;

PAOLUZI, P ;

PALLONE, F ;

DAS, KM .

GASTROENTEROLOGY, 1995, 109 (01) :3-12

[7] The Th1/Th2 balance in autoimmunity [J].

Charlton, B ;

Lafferty, KJ .

CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (06) :793-798

[8]

DAWSON RMC, 1986, DATA BIOCH RES, P541

[9] NEUTROPHIL CYTOPLASMIC ANTIBODIES (P-ANCA) IN ULCERATIVE-COLITIS [J].

ELLERBROEK, M ;

POOL, MO ;

RIDWAN, BU ;

DOLMAN, KM ;

VONBLOMBERG, BME ;

VONDEMBORNE, AEGK ;

MEUWISSEN, SGM ;

GOLDSCHMEDING, R .

JOURNAL OF CLINICAL PATHOLOGY, 1994, 47 (03) :257-262

[10] ANTIBODIES TO SACCHAROMYCES-CEREVISIAE IN PATIENTS WITH CROHNS-DISEASE AND THEIR POSSIBLE PATHOGENIC IMPORTANCE [J].

GIAFFER, MH ;

CLARK, A ;

HOLDSWORTH, CD .

GUT, 1992, 33 (08) :1071-1075

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