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HATs on and beyond chromatin

被引：150
作者：
Chen, HW [1 ]
Tini, M
Evans, RM
机构：
[1] Univ Calif Davis, Ctr Canc, Basic Sci Program, Dept Biol Chem, Sacramento, CA 95817 USA
[2] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(00)00200-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The role of histone acetylation as a key mechanism of transcriptional regulation has been well established. Recent advances suggest that histone acetyltransferases also play important roles in histone-modulated processes such as DNA replication, recombination and repair. In addition, acetylation of transcriptional cofactors and other proteins is an efficient means of regulating a diverse range of molecular interactions As new histone acetyltransferases and substrates are rapidly emerging, it is becoming apparent that protein acetylation may rival phosphorylation as a mechanism to transduce cellular regulatory signals.
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页码：218 / 224
页数：7
相关论文
共 76 条
  • [1] Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A
    Ait-Si-Ali, S
    Ramirez, S
    Barre, FX
    Dkhissi, F
    Magnaghi-Jaulin, L
    Girault, JA
    Robin, P
    Knibiehler, M
    Pritchard, LL
    Ducommun, B
    Trouche, D
    Harel-Bellan, A
    [J]. NATURE, 1998, 396 (6707) : 184 - 186
  • [2] Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila
    Akhtar, A
    Becker, PB
    [J]. MOLECULAR CELL, 2000, 5 (02) : 367 - 375
  • [3] NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p
    Allard, S
    Utley, RT
    Savard, J
    Clarke, A
    Grant, P
    Brandl, CJ
    Pillus, L
    Workman, JL
    Côté, J
    [J]. EMBO JOURNAL, 1999, 18 (18) : 5108 - 5119
  • [4] Acetylation of importin-α nuclear import factors by CBP/p300
    Bannister, AJ
    Miska, EA
    Görlich, D
    Kouzarides, T
    [J]. CURRENT BIOLOGY, 2000, 10 (08) : 467 - 470
  • [5] Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex
    Barlev, NA
    Poltoratsky, V
    Owen-Hughes, T
    Ying, C
    Liu, L
    Workman, JL
    Berger, SL
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (03) : 1349 - 1358
  • [6] Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes
    Bergel, M
    Herrera, JE
    Thatcher, BJ
    Prymakowska-Bosak, M
    Vassilev, A
    Nakatani, Y
    Martin, B
    Bustin, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (15) : 11514 - 11520
  • [7] Regulation of activity of the transcription factor GATA-1 by acetylation
    Boyes, J
    Byfield, P
    Nakatani, Y
    Ogryzko, V
    [J]. NATURE, 1998, 396 (6711) : 594 - 598
  • [8] A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity
    Chakravarti, D
    Ogryzko, V
    Kao, HY
    Nash, A
    Chen, HW
    Nakatani, Y
    Evans, RM
    [J]. CELL, 1999, 96 (03) : 393 - 403
  • [9] Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein
    Champagne, N
    Bertos, NR
    Pelletier, N
    Wang, AH
    Vezmar, M
    Yang, Y
    Heng, HH
    Yang, XJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) : 28528 - 28536
  • [10] Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
    Chen, HW
    Lin, RJ
    Xie, W
    Wilpitz, D
    Evans, RM
    [J]. CELL, 1999, 98 (05) : 675 - 686
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